SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19

Researchers detected SARS-CoV-2 S-reactive CD4+ T cells in 83% of patients with COVID-19 but also in 35% of unexposed health donors (HD). The presence of S-cross-reactive T cells is probably generated during past encounters with endemic coronaviruses.  The presence of S-cross-reactive T cells in a sizable fraction of the general population may afect the dynamics of the current pandemic, and has important implications for the design and analysis of upcoming COVID-19 vaccine trials. Nature

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