Sequential immunization induces strong and broad immunity against all four dengue virus serotypes

A major challenge in dengue vaccine development is the need to induce immunity against four dengue (DENV) serotypes. The study tested whether sequential immunization induces stronger and broader immunity against four DENV serotypes than tetravalent-formulated immunization in mice. Sequential immunization induced higher levels of neutralizing antibodies to all four DENV serotypes than tetravalent vaccination. Nature Partnet Journals Vaccines

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