Association of Dengue Virus and Leptospira Co-Infections with Malaria Severity

Plasmodium infections are co-endemic with infections caused by other agents of acute febrile illnesses, such as dengue virus (DENV), chikungunya virus, Leptospira spp., and Orientia tsutsugamushi. Co-infections may influence disease severity, treatment outcomes, and development of drug resistance.  In areas with a large number of severe malaria cases, diagnostic screening for all 4 DENV serotypes, Leptospira, and all Plasmodium species should be performed. Emerging Infectious Diseases

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