Use of controlled temperature chain and compact prefilled auto-disable devices to reach 2030 hepatitis B birth dose vaccination targets in LMICs: a modelling and cost-optimisation study

Jun 25, 2020

The study investigates the effects and cost-effectiveness of implementing ambient storage of hepatitis B vaccines under a controlled temperature chain (CTC) protocol and the use of compact prefilled auto-disable (CPAD) devices for community births. Without making changes to current birth dose protocols such that vaccines must be stored in the cold-chain and administered by professional health workers, coverage could only increase from 44% to 65%;  The modelling shows that reaching 90% birth dose coverage with the use of CTC and CPAD interventions in the six GBD regions could avert 36·3 million Disability Adjusted Life Years DALYs during each birth cohort's lifetime and be cost saving overall. The Lancet Global Health


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