Estimates of the global burden of Japanese encephalitis and the impact of vaccination from 2000-2015

Japanese encephalitis (JE) is a mosquito-borne disease, known for its high mortality and disability rate among symptomatic cases. Many effective vaccines are available for JE, and the use of a recently developed and inexpensive vaccine, SA 14-14-2, has been increasing over the recent years. Estimates of the local burden and the past impact of vaccination are therefore increasingly needed, but difficult due to the limitations of JE surveillance. Research estimated that in 2015 there were around 100,000 JE cases globally. In addition, we estimate that vaccination programs averted around 45,000 JE cases in 2015. Research estimate that India, Timor-Leste, and Vietnam  have high transmission intensity, and residual cases despite vaccination, and therefore could further benefit from scaling-up the existing vaccination program. Additionally, reseach estimated high transmission intensity in Indonesia, Papua New Guinea, and Philippines where there are no current vaccination programs, suggesting that vaccination in these areas should be a future priority. eLife

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