Pharmacologic Treatments and Supportive Care for Middle East Respiratory Syndrome

The systematic review identified 3 nonrandomized single-arm intervention studies, 12 cohort studies, and 5 case series evaluating specific treatments and supportive care for MERS patients. Most studies were at serious or critical RoB because of confounding and selection bias. Low-quality evidence (based on a single study) indicates a benefit from ECMO in severe MERS cases. Low-quality evidence also exists showing no benefit of corticosteroids, NIV, macrolides, or combination of ribavirin with any type of IFN. Collaborative clinical trials evaluating potential therapies are urgently needed to guide treatment decisions. Emerging Infectious Diseases

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